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KMID : 0377619670130050479
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Korean Jungang Medical Journal
1967 Volume.13 No. 5 p.479 ~ p.486
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Rabbit Serum Glucose and Protein in Hemorrhagic Shock
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Kang, S. Y./姜聲瑢
Han, S. K./Cho, S. J./Kim, S. W./韓淳甲/趙壽貞/金昇元
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Abstract
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In order to investigate the regeneration of the serum proteins and hemoglobin bleeding has often been employed as a physiological technique. Using, the same technique it is hoped in the present work to observe the variations in the serum glucose and protein concentrations, because irreversible hemorrhagic shock poses a great deal of clinical problems and it is more than serious when it leads to death.
Werner (1) reported increase in the concentrations of the protein-bound carbohydrates of the rabbit serum after single or repeated bleedings. But Weimer et al. (2.) showed -no statistically significant increases in total serum glyco-protein or seromucoid. levels in guinea pigs bled at weekly intervals, but significant decreases were noted in the bound-carbonhydrate of the r-globulin
fraction. In view of these conflicting results, Kang (3) reported recently that the serum β-lipoprotein and glyco-protein as well as phospholipid were significantly reduced as compared to those of normal rabbits when they are subjected to repeated bleeding.
As is well understood, the mechanism governing the development and con-
sequences of post-hemorrhagic circulatory collapse has been tentatively related to
the activation of the sympathetico-adrenal system. During an early reversible
stage after hemorrhage, this activation leads to compensatory re-adjustments; in a
later irreversible stage the persisting sympathetico-adrenal activity brings about
vascular and tissue lesions, especially at sites exposed to prolonged vasoconstric-
tion. At this stage the situation cannot be remedied by restoring the blood volume.
Therefore, the authors were interested in the celar pictures of alterations in
the serum and protein contents in the rabbit when they were repeatedly bled in an effort to explain some features pertaining to the carbohydroate and protein metabolism involved in the irreversible hemorrhagic shock.
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